Using Efudix (Fluorouracil)

Apply enough Efudix (Fluorouracil) to cover the entire affected area with a thin layer. Keep using Efudix (Fluorouracil) for the full time of treatment. Do not use Efudix (Fluorouracil) more often or for a longer time than your doctor ordered.

Washing the area with soap and water and dry. Use a cotton-tipped applicator or your fingertips to apply Efudix (Fluorouracil) in a thin layer to the problem area.

If you apply Efudix (Fluorouracil) with your fingertips, wash your hands immediately afterwards, to prevent any of the Efudix (Fluorouracil) from accidentally getting in your eyes or mouth.

Efudix (Fluorouracil) may cause redness, soreness, scaling, and peeling of affected skin after 1 or 2 weeks of use. This may last for several weeks after you stop using Efudix (Fluorouracil). Sometimes a pink, smooth area is left when the skin treated with Efudix (Fluorouracil) heals. This area will usually fade after 1 to 2 months. Do not stop using Efudix (Fluorouracil) without first checking with your doctor. If the reaction is very uncomfortable, check with your doctor.

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Dose of Efudix (Fluorouracil)

Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Efudix (Fluorouracil). If your doctor has recommended a different dose of Efudix (Fluorouracil), do not change it unless your doctor tells you to do so.

For cream dosage form of Efudix (Fluorouracil)

For precancerous skin condition caused by the sun:

Adults: Use the 1% Efudix (Fluorouracil) cream on the affected areas of skin one or two times a day.

The 5% Efudix (Fluorouracil) cream is sometimes used on the hands.

Children: Use and dose of Efudix (Fluorouracil) for children must be determined by your doctor.

For skin cancer:

Adults: Use the 5% Efudix (Fluorouracil) cream on the affected areas of skin two times a day. Treatment may continue for several weeks.

Children: Use and dose of Efudix (Fluorouracil) must be determined by your doctor.

For topical Efudix (Fluorouracil) solution dosage form:

For precancerous skin condition caused by the sun:

Adults: Use the 1% Efudix (Fluorouracil) solution on the affected areas of skin one or two times a day. The 2% or 5% Efudix (Fluorouracil) solution is sometimes used on the hands.
Children:Use and dose must be determined by your doctor.

For skin cancer:

Adults: Use the 5% Efudix (Fluorouracil) solution on the affected areas of skin two times a day. Treatment may continue for several weeks.
Children: Use and dose must be determined by your doctor.

Storage of Efudix (Fluorouracil):

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Protect the solution from freezing.
• Do not keep outdated medicine or medicine no longer needed.
• Be sure that any discarded medicine is out of the reach of children.

Precautions when using Efudix (Fluorouracil):

Apply this medicine very carefully when using it on your face.

Avoid getting any in your eyes, nose, or mouth.

While using this medicine, and for 1 or 2 months after you stop using it, your skin may become more sensitive to sunlight than usual and too much sunlight may increase the effect of the drug. During this period of time:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
• Wear protective clothing, including a hat and sunglasses.
• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
• Do not use a sunlamp or tanning bed or booth.
• If you have a severe reaction from the sun, check with your doctor.

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Side Effects of Efudix (Fluorouracil)

Check with your doctor immediately if the normal skin outside of the applied area becomes red and swollen.

Other side effects may occur:

More common: Burning feeling where medicine is applied; increased sensitivity of skin to sunlight; itching ; oozing; skin rash; soreness or tenderness of skin

Less common or rare: Darkening of skin; scaling; watery eyes

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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